Cancer – Leukemia

What is Leukemia?

Leukemia (Greek leukos λευκός, “white”; aima αίμα, “blood”) is a cancer of the bloodbone marrow and is characterized by an abnormal proliferation (production by multiplication) of blood cells, usually white blood cells (leukocytes). Leukemia is a broad term covering a spectrum of diseases. In turn, it is part of the even broader group of diseases called hematological neoplasms. or

(Wikipedia)

Marijuana Facts and Resources:

  • Cannabis-induced cytotoxicity in leukemic cell lines
    “We have shown that THC is a potent inducer of apoptosis, even at 1 x IC50 (inhibitory concentration 50%) concentrations and as early as 6 hours after exposure to the drug. These effects were seen in leukemic cell lines (CEM, HEL-92, and HL60) as well as in peripheral blood mononuclear cells. Additionally, THC did not appear to act synergistically with cytotoxic agents such as cisplatin. One of the most intriguing findings was that THC-induced cell death was preceded by significant changes in the expression of genes involved in the mitogen-activated protein kinase (MAPK) signal transduction pathways.”
  • Cannabidiol-Induced Apoptosis in Human Leukemia Cells
    “Furthermore, cannabidiol-induced apoptosis and reactive oxygen species (ROS) levels could be blocked by treatment with the ROS scavengers or the NAD(P)H oxidase inhibitors. Finally, cannabidiol exposure led to a decrease in the levels of p-p38 mitogen-activated protein kinase, which could be blocked by treatment with a CB2-selective antagonist or ROS scavenger. Together, the results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22phox expression, may be a novel and highly selective treatment for leukemia.”
  • Targeting CB2 cannabinoid receptors to treat malignant lymphoblastic disease
    “The results showed that exposure to THC led to a dramatic reduction in the number of viable tumor cells.”
  • Cannabinoids induce incomplete maturation of cultured human leukemia cells (1987)
  • {Delta}9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells
    “Plant-derived cannabinoids, including 9-tetrahydrocannabinol (THC), induce apoptosis in leukemic cells, although the precise mechanism remains unclear.”
  • Cannabidiol inhibits tumour growth in leukaemia and breast cancer
    “Italian researchers investigated the anti-tumour effects of five natural cannabinoids of the cannabis plant (cannabidiol, cannabigerol, cannabichromene, cannabidiol-acid and THC-acid) in breast cancer. Cannabidiol (CBD) was the most potent cannabinoid in inhibiting the growth of human breast cancer cells that had been injected under the skin of mice.”
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